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KMID : 0545120220320050612
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Journal of Microbiology and Biotechnology
2022 Volume.32 No. 5 p.612 ~ p.620
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Postbiotics Enhance NK Cell Activation in Stress-Induced Mice through Gut Microbiome Regulation
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Jung Ye-Jin
Kim Hyun-Seok
Jaygal Gunn
Cho Hye-Rin
Lee Kyung-Bae
Song In-Bong
Kim Jong-Hoon
Kwak Mi-Sun
Han Kyung-Ho
Bae Min-Jung
Sung Moon-Hee
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Abstract
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Recent studies have revealed that probiotics and their metabolites are present under various conditions; however, the role of probiotic metabolites (i.e., postbiotics in pathological states) is controversial. Natural killer (NK) cells play a key role in innate and adaptive immunity. In this study, we examined NK cell activation influenced by a postbiotics mixture in response to gut microbiome modulation in stress-induced mice. In vivo activation of NK cells increased in the postbiotics mixture treatment group in accordance with Th1/Th2 expression level. Meanwhile, the Red Ginseng treatment group, a reference group, showed very little expression of NK cell activation. Moreover, the postbiotics mixture treatment group in particular changed the gut microbiome composition. Although the exact role of the postbiotics mixture in regulating the immune system of stress-induced mice remains unclear, the postbiotics mixture-induced NK cell activation might have affected gut microbiome modulation.
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KEYWORD
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Postbiotics mixture, natural killer cell, fecal microbiome, immune response
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